Upstream Sex and Gender Integration Marker
This Upstream Sex and Gender Integration Marker is a learning tool for the foundation’s upstream health investments. It is intended to be used by investment owners when designing and refining an investment and to spark conversation with grantees.
The purpose of this tool is to enable investment owners and teams to more intentionally integrate relevant considerations on:
- Sex as a biological variable—anatomy, physiology, genetics, hormones, etc.—and/or
- Gender —social variables such as roles, norms, relations, and power.
The tool was updated in November 2024.
Download Upstream Sex and Gender Integration Marker
For additional resources and learning, see below a non-exhaustive selection of materials including self-paced e-learning.
Resources
Additional Resources
- Design, Analyze and Communicate (DAC) resource: Points to Consider for integrating sex and gender in clinical trials. DAC is an available resource for Bill and Melinda Gates Foundation grantees undergoing clinical trials. Learn more about DAC.
- Women’s Health Innovation Opportunity Map 2023: Issued by the Innovation Equity Forum, a group of 250+ experts and stakeholders in women’s health R&D.
- Sex and Gender in Research (SAGER Guidelines): Developed to ensure sex and gender are systematically considered and reported across disciplines.
- Sex Inclusive Research Framework: An evaluation tool to assess in vivo research proposals for sex inclusive approach.
- NIH’s Sex as a Biological Variable (SABV) policy.
- Health Canada’s Sex and Gender-Based Analysis Plus.
- European Medicines Agency (EMEA) Gender Considerations in Clinical Trials.
- FDA’s Evaluation of Sex-Specific Data in Medical Device Clinical Studies.
Self-service learning
NIH Office of Research on Women’s Health e-learning courses are free and open to the public. Topics include:
- Sex as a biological variable (SABV) primer
- Bench to Bedside: Integrating sex and gender to improve human health
- Introduction to Sex and gender: core concepts for health-related research
Canada’s Institute of Gender and Health offers free, open access and interactive training modules to integrate sex and gender across health research. Topics include:
- Sex and gender in biological research
- Sex and gender primary data collection with human participants
- Sex and gender in the analysis of secondary data from human participants